Lab Director
Carlo
C. Maley, Ph.D.
Associate Adjunct Professor
Director, Center for Evolution and Cancer
UCSF Helen Diller Family Comprehensive Cancer Center
Support the Research
A gift to the Maley Lab helps us understand and prevent relapse after therapy as well as preventing cancer.
Applying Evolutionary & Ecological Theory to Neoplastic Progression and Cancer Therapy
The Maley laboratory studies the evolution of clones during neoplastic progression of Barrett's esophagus, and the selective effects of therapy in acute myeloid leukemia (AML) and esophageal adenocarcinoma. It is also developing the comparative biology of cancer to determine how large, long-lived organisms like whales are able to suppress cancer 1000-fold over humans. The lab applies evolutionary and ecological theory to neoplastic progression and cancer therapy to modulate the evolution of neoplastic cells, thereby preventing cancer and its relapse. Our driving questions include:
- Can we measure the rate of somatic evolution to predict which patients are likely to progress to cancer and relapse after therapy?
- How can we slow the rate of somatic evolution in order to prevent cancer and relapse after therapy?
- What causes resistance to cancer therapy and how can we prevent that resistance?
Recent Publications
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